AO-176 is a highly differentiated, best-in-class anti-CD47 antibody with the potential to improve upon the safety and efficacy profile of other agents in this class of checkpoint inhibitors. AO-176 works by blocking the “don’t eat me” signal for macrophages, the standard mechanism of anti-CD47 antibodies. However, beyond blocking this signal, AO-176 has additional mechanisms including both directly killing tumor cells and inducing DAMPs (Damage Associated Molecular Patterns) resulting in Immunogenic Cell Death. Importantly, AO-176 binds preferentially to CD47 on tumor cells, instead of normal cells, and binds even more potently in low pH conditions such as the tumor microenvironment.
AO-176 is advancing in a multicenter Phase 1/2 clinical trial in combination with chemotherapy for patients with solid tumors. In a Phase 1 clinical trial in solid tumors, AO-176 demonstrated encouraging evidence of anti-tumor activity when administered as a single agent. Additional information about this trial may be found at www.clinicaltrials.gov using the trial identification number NCT03834948.
AO-176 also has an active IND for a Phase 1 clinical trial for the treatment of patients with multiple myeloma. Information for this trial can be found under the number NCT04445701 at the same site.